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| EVOLUTE® ABN - New Column Configurations! |
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| 28.01.08 | |
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EVOLUTE®
ABN is an advanced water-wettable polymer-based sorbent that extracts
acidic, basic and neutral analytes from biological fluids and other
aqueous matrices. Developed specifically for analyte quantification by
LC-MS/MS, EVOLUTE products provide a highly effective solution to the
problems of ion suppression and matrix effects from dirty extracts.
These high performance products allow scientists to use a generic
approach for a wide range of compounds, thus reducing method
development time while producing super clean extracts.
• Minimal ion suppression • Four times higher signal intensity in LC-MS/MS • Fast, simple generic methodology • High, reproducible recoveries for a wide range of analytes  Figure 1. The optimized pore structure prevents retention of endogenous large molecular weight interferences, allowing analytes to be eluted in extremely clean extracts. EVOLUTE ABN Sample Preparation Products are available in a range of Standard Configurations. Ultra-Clean Extracts EVOLUTE ABN’s optimized pore structure minimizes the retention of high molecular weight endogenous materials present in complex sample matrices. See Figure 1. The result is cleaner extracts, providing four times higher signal to noise and improved LC-MS/MS quantitation. See Figure 2 below.  Figure 2. LC-MS/MS signal (m/z 195>138) for caffeine spiked plasma, compared to spiked mobile phase (flow injection analysis). EVOLUTE ABN gives four times higher s/n than a resin-based product. Simple and fast method development EVOLUTE ABN uses a single generic procedure suitable for a wide range of analytes and aqueous matrices. Without secondary interactions, pure organic elution solvents can be used, reducing evaporation time and providing optimal LC-MS/MS compatibility, making the transfer to analysis more efficient. High analyte recoveries EVOLUTE ABN has a unique modified surface structure that is water-wettable to promote robust, reliable sample preparation. A balanced combination of polar (hydrophilic) and non-polar (hydrophobic) interactions allows efficient extraction of analytes of wide ranging polarity. Excellent flow characteristics EVOLUTE ABN’s narrow particle size distribution provides consistent flow characteristics for a variety of sample matrices. Optimized packing techniques eliminate channeling, which can lead to analyte breakthrough. Batch-to-batch reproducibility The surface characteristics of every batch of EVOLUTE ABN are quality controlled and tested to ensure consistency. |
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| Τελευταία ανανέωση ( 27.05.08 ) |
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